Intestinal Spirochetosis

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Intestinal spirochetosis: a “fuzzy” entity

The presence of spirochetes in the human bowel has been recognized for over a century. Harland in 1967 described spirochetes on electron microscopy of rectal biopsies in a man with chronic diarrhea, and coined the term intestinal spirochetosis (IS) [1]. We report two cases of IS followed by review of literature. A 23-year-old male homosexual presented with diarrhea for 9 months but no blood. Th...

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Human intestinal spirochetosis – a review

Human intestinal spirochetosis (IS) is a condition defined histologically by the presence of spirochetal microorganisms attached to the apical cell membrane of the colorectal epithelium. Intestinal spirochetes comprise a heterogeneous group of bacteria. In humans, Brachyspira aalborgi and Brachyspira pilosicoli predominate. Prevalence rates of IS are low where living standards are high, in cont...

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Intestinal spirochetosis presenting as acute appendicitis

Acute appendicitis is a frequent pathology encountered by general surgeons. On the differential of aetiologies that can lead to this diagnosis lies the spectrum of infectious disease. We present a case report of a patient who presented to our institution as a classic acute appendicitis. Upon histological analysis it became evident that he had spirochetosis of the cecum and appendix. This paper ...

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Intestinal Spirochetosis mimicking inflammatory bowel disease in children

BACKGROUND Intestinal spirochetosis is an unusual infection in children and its clinical significance in humans is uncertain. The presence of these microorganisms in humans is well-known since the late 1800's and was first described in 1967 by Harland and Lee by electron microscopy. CASE PRESENTATION This article reports the findings of one pediatric case, review of the current literature, an...

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Treponema pallidum Immunohistochemistry is positive in human intestinal Spirochetosis.

BACKGROUND Human intestinal spirochetosis (IS) has been recognized for decades, but whether it represents commensalism or a pathogenic process remains controversial. IS is diagnosed on routine stains with confirmation by silver stains but these stains are labor intensive and slow to read. We evaluated the Treponema pallidum immunostain as a diagnostic adjunct for IS. METHODS We retrieved biop...

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ژورنال

عنوان ژورنال: Mayo Clinic Proceedings

سال: 2020

ISSN: 0025-6196

DOI: 10.1016/j.mayocp.2019.12.003